Resources » Videos » Large-Volume Autoinjector Testing and Partial Torsion Cap Removal

Large-Volume Autoinjector Testing and Partial Torsion Cap Removal

Instron's Autoinjector Testing System for Large-Volume Devices is designed to evaluate the performance, functionality, and usability of large-volume autoinjectors (3+ mL). Featuring an enlarged device interface, the system accommodates a wide range of autoinjector and cap geometries. Device-specific adapters securely hold the autoinjector throughout testing to ensure consistent, repeatable results and can be quickly exchanged to support different device designs.

The automated test sequence includes:

Cap removal force
Activation force
Audible click detection
Injection time
Needle depth measurement
Delivered volume verification
Lockout check (pass/fail)

For autoinjectors that require partial rotation cap removal, the system can be equipped with Instron's Limited Rotation Torsion Add-On 3.0, providing ±90° rotational capability for both standard and large-volume autoinjectors. The torsional cap-removal sequence is fully customizable to meet specific device requirements and test protocols.

For laboratories requiring System Suitability Testing (SST), a dedicated SST device is available for daily verification of the biaxial load cell, helping ensure reliable system performance, measurement accuracy, and repeatable test results.

[00:04] Autoinjector Testing System: For Large-Volume Devices / Partial Torsion Cap Removal

[00:13] System Overview: System Enclosure with Light Curtain, Autoinjector Testing System / 6800 Series Frame

[00:23] Limited Rotation Torsion Add-On 3.0: +/- 90° (For Rotational Cap Removal/Device Unlocking), Biaxial Load Cell, Upper Pneumatic Gripper, Device-Specific Adapter

[00:35] The system is designed to support a wide range of device and cap geometries.

[00:44] A device-specific adapter secures the autoinjector for consistent cap removal.

[00:57] Complete Test Sequence: Cap removal force, activation force, audible click detection, injection time, needle depth, delivered volume, lockout check pass/fail.

[01:12] Autoinjector Testing System: Partial Torsion Cap Removal

[01:18] The device-specific cap adapter can be easily swapped to accommodate different autoinjector types.

[01:24] Limited Rotation Torsion Add-On 3.0: +/-90° rotation for cap removal and device unlocking on standard and large-volume devices.

[01:36] Rotational sequence is customizable depending on device requirements.

[02:03] System suitability test device provides a daily verification of the biaxial load cell operation.

Related Videos

Introducing Instron’s Next Generation Autoinjector Testing System

This webinar shows the Autoinjector Testing System's full functionality testing, Bluehill^® Universal method templates, essential performance measurements, system suitability, and tools that streamline validation for a wide range of autoinjector devices.

Autoinjector: Device Changeover and System Alignment

The Autoinjector Testing System’s fixtures are designed to minimize side loading during cap removal and support common industry device geometries, while offering flexibility to easily accommodate customized devices.

Autoinjector Testing System: Simple Test Methods

Bluehill Universal uses simplified test types that empower users to develop and change method parameters with ease, while offering the flexibility to readily accommodate future devices without requiring Instron’s support.